Table 1.
Genetic loci found to be associated with increased HZ risk in the European ancestry GWAS*
| Allele | Time to HZ event† |
Incidence of HZ (case versus control)‡ |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease, ethnicity | Locus | Chr |
Reference SNP ID |
Position |
Reference allele |
Alternative allele |
Alternative allele frequency |
HR (95% CI) | P | OR (95% CI) | P |
| RA | |||||||||||
| European | PMEPA1 | 20 | rs59967896 | 56216698 | T | TCAA | 0.03 | 3.75 (2.46–5.71) | 8.34 × 10−10 | 4.1 (2.51–6.69) | 2.34 × 10−7 |
| PsO | |||||||||||
| European | CD83 | 6 | rs112817503 | 14292820 | C | T | 0.03 | 5.74 (3.38–9.77) | 1.14 × 10−10 | 7.71 (4.02–14.8) | 6.25 × 10−8 |
| European | UGDH | 4 | rs150665541 |
39536523 |
C | T | 0.03 | 4.86 (2.79–8.45) | 2.10 × 10−8 | 5.46 (2.88–10.3) | 3.57 × 10−6 |
| European | VWF | 12 | rs200638456 |
6102826 |
T | TAC | 0.07 | 3.5 (2.25–5.46) | 2.94 × 10−8 | 4.04 (2.42–6.75) | 1.08 × 10−6 |
GWAS = genome‐wide association study; Chr = chromosome; SNP ID = single‐nucleotide polymorphism cluster identification; HR = hazard ratio; 95% CI = 95% confidence interval; OR = odds ratio; RA = rheumatoid arthritis; PsO = psoriasis.
Results of the Kaplan‐Meier analyses of time to herpes zoster (HZ) event are presented in Supplementary Figure 4 (available on the Arthritis & Rheumatology website at http://onlinelibrary.wiley.com/doi/10.1002/art.41655/abstract).
C‐statistics for the case versus control logistic regression model are presented in Supplementary Table 5 (available on the Arthritis & Rheumatology website at http://onlinelibrary.wiley.com/doi/10.1002/art.41655/abstract).