TABLE 1.
Concordance Index (C‐index) for Univariate Cox Model Using Each of the ML‐Based Features, Features Scored by the CP
| Patient Population | Features | C‐index [95% CI] (Cox Proportional Hazards Model) | |
|---|---|---|---|
| ML | CP | ||
| STELLAR 3; N = 113 (patients with progression to cirrhosis) | Inflammation | 0.55 [0.49‐0.55] | 0.52 [0.49‐0.55] |
| Steatosis | 0.57 [0.52‐0.62] | 0.51 [0.50‐0.54] | |
| Ballooning | 0.55 [0.51‐0.60] | 0.53 [0.50‐0.56] | |
| Ishak | 0.62 [0.57‐0.67] | 0.58 [0.54‐0.61] | |
| STELLAR 4; N = 22 (patients with adjudicated clinical events) | Inflammation | 0.57 [0.48‐0.73] | 0.57 [0.49‐0.65] |
| Steatosis | 0.67 [0.55‐0.77] | 0.52 [0.50‐0.58] | |
| Ballooning | 0.64 [0.52‐0.75] | 0.53 [0.50‐0.60] | |
| Ishak | 0.73 [0.63‐0.81] | 0.65 [0.59‐0.71] | |
The C‐index is a generalization of the AUC and measures the discriminatory ability of the model for survival times. ML features include inflammation, steatosis, ballooning, and Ishak score.