TABLE 2.
SNPs at the Four Loci Associated With Cluster Headache Discovery Sample
| SNP | Chr:Pos EA:NEAa | EAF | OR [95% CI] | p valueb | Nearest genec | eQTL mapped genesd |
|---|---|---|---|---|---|---|
| rs11579212 | 1:222072819 C:A | 0.34 | 1.51 [1.33–1.72] | 4.78 × 10−10 | RP11‐815 M8.1 | DUSP10 |
| rs6541998 | 2:112785237 C:T | 0.63 | 1.53 [1.37–1.74] | 1.91 × 10−10 | MERTK | TTL POLR1B FBLN7 ZC3H8 MERTK TMEM87B RGPD8 ZC3H6 |
| rs10184573 | 2:200448253 T:G | 0.44 | 1.43 [1.26–1.61] | 2.20 × 10−8 | AC093590.1 | SATB2 FTCDNL1 |
| rs2499799 | 6:96851676 C:T | 0.81 | 0.62 [0.54–0.73] | 1.29 × 10−9 | UFL1/FHL5 | UFL1 FHL5 GPR63 MMS22L FUT9 |
a
Chromosomal positions in GRCh37/hg19 coordinates.
b
Significant result (p < 5 × 10−8).
c
The nearest gene is based on ANNOVAR annotations with Ensembl build version 85.
d
The eQTL mapping was done in FUMA based on GTEx version 8.
Chr = chromosome; CI = confidence interval; EA = effect allele; EAF = effect allele frequency; NEA = non effect allele; OR = odds ratio; Pos = position; SNP = single nucleotide polymorphism.