TABLE 3.

Replication of the Significant Loci in an Independent Sample

L	Chr	SNP discovery sample	SNP replication sample	Posa	OR [95% CI]	p valueb	Directionc
1	1	rs11579212	rs11579212	222072819	1.58 [1.16–2.15]	3.50 × 10−3	+
2	2	rs6541998	rs6541998	112785237	1.04 [0.78–1.40]	0.78	+
3	2	rs10184573	rs10184573	200448253	1.74 [1.29–2.34]	2.78 × 10−4	+
4	6	rs2499799	rs976357 (r 2 = 1.0)	96849679	0.44 [0.30–0.64]	2.76 × 10−5	+

^a Chromosomal positions in GRCh37/hg19 coordinates for the replication SNP.

^b Significant result (p < 0.05/4).

^c Direction; Same (+) or opposite (−) direction of association for discovery and replication analyses.

Chr = chromosome; CI = confidence interval; L = locus number; OR = odds ratio; Pos = chromosomal position; SNP = single nucleotide polymorphism.