TABLE 4.
The Association of Previously Reported Cluster Headache Loci in Our Discovery Cluster Headache Sample
| Previously reported CH loci | Association with CH discovery sample | ||||||
|---|---|---|---|---|---|---|---|
| Nearest coding gene | Index SNP | EA | OR [95%CI] | p value | Ref | OR [95%CI] | pcorr‐valuea |
| ADCYAP1R1 | rs12668955 | G | 0.48 [0.34–0.07] | 9.1 × 10−6 | 13 | 1.05 [0.91–1.21] | 1 |
| ADH4 | rs1126671 | A | 2.33 [1.25–4.37] | 0.006b | 29 | 0.87 [0.76–0.99] | 0.36 |
| ADH4 | rs1126671 | A | ‐ | 0.03 | 30 | 0.87 [0.76–0.99] | 0.36 |
| ADH4 | rs1800759 | A | ‐ | 0.03 | 30 | 0.80 [0.70–0.90] | 0.0035 |
| CLOCK | rs12649507 | A | 1.29 [1.08–1.54] | 0.02 | 28 | 0.92 [0.80–1.05] | 1 |
| CHRNA3‐CHRNA5 | rs578776 | A | ‐ | 0.038 | 26 | 0.95 [0.83–1.09] | 1 |
| HCRTR2 | rs2653349 | G | 6.79 [2.25–22.99] | < 0.0002 | 8 | 1.08 [0.93–1.26] | 1 |
| HCRTR2 | rs2653349 | G | 1.97 [1.32–2.92] | 0.0007 | 10 | 1.08 [0.93–1.26] | 1 |
| HCRTR2 | rs3122156 | G | 0.82 [0.68–0.99] | 0.0421 (P corr 0.126) | 9 | 0.92 [0.80–1.06] | 1 |
| HCRTR2 | rs10498801 | G | 0.69 [0.49–0.97] | 0.030 | 27 | 1.03 [0.88–1.21] | 1 |
| MME | rs147564881 | C | ‐ | 0.019 | 13 | 0.24 [0.42–41.51] | 1 |
The SNPs previously reported to be associated with cluster headache and the corresponding OR (based on the same EA) and p values for these SNPs in the discovery sample.
a
The p values were Bonferroni corrected for 9 tests.
b
The p value is based on the carriers with homozygous AA genotype compared with GG/GA genotypes.
CH = cluster headache; CI = confidence interval; EA = effect allele; OR = odds ratio; SNP = single nucleotide polymorphism.