Table 2.
Univariate and multivariate logistic analyses of distant metastasis in osteosarcoma patients.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | P | OR | 95%CI | P | |
| Age, years | ||||||
| ≤18 | Reference | Reference | ||||
| 19–30 | 0.456 | 0.279–0.748 | 0.002 | 0.499 | 0.299–0.832 | 0.008 |
| 31–49 | 0.190 | 0.086–0.418 | 0.000 | 0.246 | 0.110–0.548 | 0.001 |
| ≥50 | 0.859 | 0.536–1.376 | 0.526 | 1.042 | 0.632–1.720 | 0.871 |
| Race | ||||||
| Black | Reference | |||||
| Other | 0.905 | 0.417–1.963 | 0.801 | |||
| White | 1.294 | 0.794–2.109 | 0.302 | |||
| Sex | ||||||
| Female | Reference | |||||
| Male | 1.261 | 0.892–1.782 | 0.189 | |||
| Primary site | ||||||
| Axial | Reference | |||||
| Limb | 0.882 | 0.470–1.656 | 0.696 | |||
| Other | 0.258 | 0.093–0.715 | 0.009 | |||
| Grade | ||||||
| I–II | Reference | Reference | ||||
| III–IV | 6.581 | 2.395–18.086 | <0.001 | 3.723 | 1.324–10.470 | 0.013 |
| Histological type | ||||||
| 9180 | Reference | |||||
| 9181 | 0.760 | 0.463–1.248 | 0.279 | |||
| 9182 | 0.203 | 0.048–0.848 | 0.029 | |||
| 9183 | 1.101 | 0.471–2.577 | 0.824 | |||
| 9184 | 4.562 | 0.636–32.736 | 0.131 | |||
| 9185 | 1.369 | 0.371–5.054 | 0.638 | |||
| Other | 0.329 | 0.156–0.693 | 0.003 | |||
| T | ||||||
| T1 | Reference | Reference | ||||
| T2 | 2.155 | 1.455–3.191 | <0.001 | 2.015 | 1.337–3.036 | 0.001 |
| T3 | 5.911 | 2.670–13.084 | <0.001 | 4.318 | 1.856–10.044 | 0.001 |
| N | ||||||
| N0 | Reference | Reference | ||||
| N1 | 6.851 | 3.010–15.592 | <0.001 | 6.018 | 2.503–14.468 | <0.001 |
| Tumor size, mm | ||||||
| <50 | Reference | |||||
| 50–100 | 2.466 | 1.151–5.285 | 0.020 | |||
| >100 | 4.061 | 1.910–8.636 | <0.001 | |||
9180, Osteosarcoma, NOS; 9181, Chondroblastic osteosarcoma; 9182, Fibroblastic osteosarcoma; 9183, Telangiectatic osteosarcoma; 9184, Osteosarcoma in Paget disease of bone; 9185, Small cell osteosarcoma; OR, Odds ratio; CI, Confidence interval.