Table 4.

Univariate and multivariate Cox analyses in osteosarcoma patients with DM.

	Univariate analysis			Multivariate analysis
	HR	95%CI	P	HR	95%CI	P
Age, years
≤18	Reference			Reference
19–30	1.993	1.148-3–460	0.014	1.779	1.018–3.108	0.043
31–49	2.223	0.798–6.193	0.127	2.272	0.813–6.355	0.118
≥50	6.470	3.858–10.851	<0.001	4.477	2.480–8.082	<0.001
Race
Black	Reference
Other	0.947	0.341–2.631	0.917
White	1.135	0.641–2.008	0.664
Sex
Female	Reference
Male	1.064	0.704–1.608	0.767
Primary site
Axial	Reference
Limb	0.334	0.181–0.619	<0.001
Other	0.571	0.161–2.027	0.386
Grade
I–II	Reference
III–IV	0.739	0.234–2.334	0.606
Histological type
9180	Reference
9181	1.201	0.684–2.107	0.523
9182	0.761	0.105–5.496	0.787
9183	1.640	0.708–3.799	0.248
9184	4.571	1.102–18.960	0.036
9185	3.526	1.088–11.430	0.036
Other	0.328	0.080–1.340	0.121
T
T1	Reference
T2	0.865	0.540–1.386	0.546
T3	1.146	0.532–2.469	0.727
N
N0	Reference
N1	1.729	0.868–3.443	0.119
Tumor size
<50	Reference
50–100	0.564	0.237–1.346	0.197
>100	0.705	0.303–1.638	0.416
Surgery
No	Reference			Reference
Yes	0.185	0.113–0.303	<0.001	0.226	0.134–0.382	<0.001
Chemotherapy
No	Reference			Reference
Yes	0.255	0.135–0.481	<0.001	0.485	0.238–0.990	0.047
Radiotherapy
No	Reference
Yes	2.340	1.430–3.829	0.001

9180, Osteosarcoma, NOS; 9181, Chondroblastic osteosarcoma; 9182, Fibroblastic osteosarcoma; 9183, Telangiectatic osteosarcoma; 9184, Osteosarcoma in Paget disease of bone; 9185, Small cell osteosarcoma; HR, Hazard ratio; CI, Confidence interval.