FIGURE 3.

Neuro-anatomical structures affected or for which myelination is preserved in POLR3-related disorders. (A) Schematic of a sagittal view of the human brain. Structures involved/preserved in POLR3-HLD are depicted in distinct colours and labeled with a number. On the right side, the names of anatomical structures corresponding to each number are shown in the same colour as the structure, followed by a description of how the structure is affected/preserved in POLR3-HLD. (B) Schematic of a coronal view of the human brain. Structures involved/preserved in the striatal variant of POLR3-related disorders (caudate and putamen) or in POLR3-HLD (other structures) are shown in distinct colours and labeled with a number. The legend on the right side follows the same description as in (A). White matter (in white on the brain schematic) is indicated by an arrow. Corticospinal tracts are displayed as brown dashed lines. The figure was adapted from images available on https://smart.servier.com.