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Localization of POLR1C Asn32Ile and Asn74Ser mutations that are associated with POLR3-HLD. Amino acids in POLR1C which cause an assembly defect in Pol III (Thiffault et al., 2015) upon mutation are shown in red (POLR1C Asn32) and in ochre (POLR1C Asn74). They are localized at the interface with Pol III subunits POLR3A (green) and POLR3B (turquoise). The remainder of POLR1C is colored in pink. The Figure was modified from PDB 7AE3 by employing Pymol.
