FIGURE 6.

Localization of POLR3A Met852Val and POLR3B Arg103His mutations relative to the active site. POLR3A is shown in green and POLR3B in turquoise. Pol III mutations described in the text that are found close to the active site and which may thus affect catalytic activity are depicted. Methionine 852 of POLR3A as part of the bridge helix is highlighted as a sphere in yellow. Arginine 103 of POLR3B is highlighted as a sphere in magenta. RNA is shown in red and DNA in blue. The Mg2+ ion of the active site is shown as a sphere in light orange. The Figure was modified from PDB 7AE3 by employing Pymol.