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. 2021 Jul 30;8:696438. doi: 10.3389/fmolb.2021.696438

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Copyright © 2021 Lata, Choquet, Sagliocco, Brais, Bernard and Teichmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription of the 7SL RNA gene, assembly of the signal recognition particle and functions in the secretory pathway. 7SL RNA gene transcription is directed by gene-internal A- and B-boxes as well as by an ATF/CREB-response element and a distal sequence element (DSE) upstream of the TSS. Transcription is initiated by TFIIIC- and TFIIIB-β-dependent recruitment of Pol III (1). The SRP 9/14/19/68/72 pre-signal recognition particle (pre-SRP) is assembled in the nucleus (2), exported to the cytoplasm and completed with SRP54 (3). SRP recognizes hydrophobic signal peptides in nascent polypeptide chains of secretory pathway proteins (4), arrests translation, translocates arrested ribosomes to the endoplasmic reticulum (ER), where translation resumes and proteins are translocated either into the lumen or into the membrane of the ER (5). Proteins of the secretory pathway are either incorporated into membranes or exported from cells (6). ERGIC refers to the ER-Golgi-intermediate compartment.