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. 2021 Jul 30;8:696438. doi: 10.3389/fmolb.2021.696438

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Copyright © 2021 Lata, Choquet, Sagliocco, Brais, Bernard and Teichmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription of the BC200 RNA and its functions in mRNA transport and regulation of translation. BC200 RNA gene transcription depends on TFIIIC bound to gene-internal A- and B-boxes, which allows the subsequent recruitment of TFIIIB-β and Pol III. Sequences upstream of the TSS including a TATA-like box at -30 regulate transcription activity (1). BC200 RNA assembles with SRP 9/14 in the nucleus (2) and is exported to the cytoplasm where it was shown to interact with a variety of proteins. BC200 was shown to interact with FMRP, SYNCRIP and Pur-alpha, suggesting a role in mRNA transport similar to what was demonstrated for BC1 in complex with these proteins (3). In association with eukaryotic initiation factor 4A (eIF4A) and poly A binding protein (PABP), BC200 RNA prevents the assembly of the 48S ribosomal subunit (4). This repression of translation can be counteracted by hnRNP E1/E2 binding to BC200 RNA in vitro (5).