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. 2021 May 25;73(7):1220–1232. doi: 10.1002/art.41652

Figure 6.

Figure 6

CD8+CCR10+ T cells exhibit regulatory properties. A and B, In peripheral blood mononuclear cells (PBMCs), the ex vivo fraction of memory CD8+ T cells that expressed CCR10 strongly correlated with the ex vivo fraction of CD8+ T cells that were CD25+CD127− (A) and CD25+FoxP3+ (B). Circles indicate pooled data from healthy controls. Additional data are shown in Supplementary Table 1 (http://onlinelibrary.wiley.com/doi/10.1002/art.41652/abstract). C, Examples of suppression assays are shown. Fresh PBMCs from 5 healthy controls were incubated with CellTrace Violet (CT‐violet) and cocultured with different CD8+ T cell subsets. Data regarding the gating strategy used for flow sorting are shown in Supplementary Figure 5, http://onlinelibrary.wiley.com/doi/10.1002/art.41652/abstract). D and E, The suppressive effect on CD4+ (D) and CD8+ (E) T cell proliferation was determined on day 4. Symbols represent individual subjects; bars show the median.* = P < 0.05. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.41652/abstract.