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. 2021 Jul 1;58(1):56–66. doi: 10.1002/uog.22087

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© 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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UOG-22087-FIG-0007-b — Nomogram for screening for trisomy 21 in first trimester of pregnancy (a), showing example of a case of trisomy 21 (b). Dashed arrows indicate points corresponding to individual markers and solid arrow represents overall risk score, converted from total points. In this case, fetal nuchal translucency thickness (NT) was 1.7 mm, prenasal‐thickness‐to‐nasal‐bone‐length ratio (PT/NBL) was 0.48, facial profile line (FPL) was 0, frontomaxillary facial angle (FMF) was 88.79°, mandibulomaxillary facial angle (MMF) was 95.60°, frontonasal facial angle (FNA) was 125.52°, maxilla‐nasion‐mandible angle (MNM) was 7.32°, distance between anterior edge of prefrontal skin and mandibulomaxillary line (d2) was 1.0 mm, corresponding to points of 1.71 + 1.01 + 1.73 + 2.18 + 1.27 + 5.12 + 1.82 + 2.32 = 17.16, providing a risk score in this case for trisomy 21 of 0.5.