Table 4.

Comparison of detection rates of three models in screening for trisomy 21, at false‐positive rates (FPR) of 1%, 3% and 5%

Model	Detection rate (% (95% CI)) for:
	FPR of 1%	FPR of 3%	FPR of 5%
Fetal NT and maternal age
Training set	59 (52–66)	66 (59–73)	71 (65–77)
Validation set	76 (67–84)	82 (75–90)	84 (77–91)
All markers
Training set	92 (89–96)	96 (94–99)	98 (96–100)
Validation set	92 (87–97)	94 (90–99)	95 (91–99)
LASSO model
Training set	90 (86–95)	91 (87–95)	93 (90–96)
Validation set	92 (87–97)	93 (88–98)	94 (90–99)

For each model, sensitivity in validation set was calculated according to cut‐off of training set.

LASSO, least absolute shrinkage and selection operator; NT, nuchal translucency thickness.