FIGURE 3.

Sensitivity and corneal nerve regeneration by the two RvD6 isomers. A, Experimental design to determine the biological activities of pure RR‐RvD6 and SR‐RvD6. The vehicle was used as negative control while the PEDF + DHA was used as positive reference. B, Corneal sensitivity was recorded with a non‐contact corneal esthesiometer every 3 days after injury. RR‐RvD6‐treated mice show faster sensation recovery at day 3, followed by SR‐RvD6 at day 6, and PEDF + DHA at day 9 after injury and treatment. The vehicle is used as comparative reference. Nerve density and representative whole‐mount images of PGP 9.5 (C, E) and SP (D, F) positive axons at 12 days after injury and treatment. All data were normalized to the baseline (uninjured corneas) as 100%. The p values were calculated by one‐way ANOVA, followed by Tukey's honest significant difference (HSD) multiple pairwise comparisons