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. 2021 Jul 13;73(8):1451–1460. doi: 10.1002/art.41679

Figure 4.

Figure 4

Deficiency of Tlr2, Lbp, or Cd14 abrogates the high‐fat diet (HFD)–induced acceleration of posttraumatic osteoarthritis cartilage destruction in mice. Wild‐type (WT) mice and TLR2−/−, TLR4−/−, LBP−/−, or CD14−/− mice subjected to sham surgery or destabilization of the medial meniscus (DMM) were fed a regular diet (RD) or high‐fat diet, and then euthanized 6 weeks after the surgery. A, Representative immunostained images of joint sections. The boxed areas in upper rows are shown at higher magnification in lower rows. Bars = 50 μm. B, Scoring of Osteoarthritis Research Society International (OARSI) histologic severity grade, osteophyte size, and subchondral bone plate (SBP) thickness (n = 10 mice per sham group and 12 mice per DMM group). Each symbol represents an individual mouse; bars show the mean and 95% confidence interval (for OARSI grade) or the mean ± SEM (for osteophyte size and SBP thickness). *** = P < 0.001, by Mann‐Whitney U test for OARSI grade, and by one‐way analysis of variance with Bonferroni post hoc test for osteophyte size and SBP thickness. NS = not significant.