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. 2021 Jul 13;73(8):1451–1460. doi: 10.1002/art.41679

Figure 6.

Figure 6

Deficiency of Lbp or Cd14 abrogates the up‐regulation of matrix‐degrading enzymes following treatment of mouse chondrocytes with osteoarthritis‐associated catabolic factors. Wild‐type (WT) and LBP−/− mouse chondrocytes (A) and CD14−/− mouse chondrocytes (B) were isolated, cultured, and treated for 36 hours with interleukin‐1β (IL‐1β) (1 ng/ml), IL‐6 (100 ng/ml), or lipopolysaccharide (LPS) (10 ng/ml). Levels of mRNA for matrix‐degrading enzymes (matrix metalloproteinase 3 [MMP‐3] MMP‐13, and ADAMTS‐5) were determined by quantitative reverse transcription–polymerase chain reaction analysis. Each symbol represents an individual mouse; bars show the mean ± SEM (n = 7 per group). ** = P < 0.005; *** = P < 0.001, by one‐way analysis of variance with Bonferroni post hoc test. KO = knockout; NS = not significant.