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. 2021 May 29;48(8):1171–1181. doi: 10.1111/1440-1681.13523

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© 2021 The Authors. Clinical and Experimental Pharmacology and Physiology published by John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Circ_GRHPR promotes the expression of FHL3 in the nucleus through PCBP2. (A) The RIP assay was performed on the PC‐9 and H1299 cell lines to verify the binding of PCBP2 to FHL3. Compared with IgG, PCBP2 protein aggregated a significant number of FHL3 mRNAs in non‐small cell lung cancer (NSCLC) cells. (B) PCBP2 could degrade FHL3 protein and mRNA levels in NSCLC cells. (C) circ_GRHPR promoted protein expression of FHL3 in the nucleus on the left. Circ_GRHPR promoted the expression of FHL3 mRNA in the nucleus on the right. Data are presented as the mean ± SD, p < 0.05 was considered statistically significant (*p < 0.05/**p < 0.01/***p < 0.001)