TABLE 2.
The utility of the dichotomized aMMP‐8 POCT to discriminate various periodontal case definitions
| Diagnostic accuracy measures | Periodontal case definitions | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Periodontal disease (n = 342) | Gingivitis (n = 62) | Periodontitis (n = 280) | The stages of periodontitis | p‐value P (I‐IV)/NP | p‐value G/H | p‐value I‐IV | ||||
| I (n = 65) | II (n = 65) | III (n = 121) | IV (n = 29) | |||||||
| threshold level = 10 ng/ml | ||||||||||
| Test positive (n/%) | 99 (28.9%) | 6 (9.7%) | 93 (33.2%) | 23 (35.4%) | 22 (33.8%) | 34 (28.1%) | 14 (48.3%) | <0.001 | 0.314 | 0.209 |
| Test negative (n/%) | 243 (71.1%) | 56 (90.3%) | 187 (66.8%) | 42 (64.6%) | 43 (66.2%) | 87 (71.9%) | 15 (51.7%) | <0.001 | 0.314 | 0.209 |
| Performance | ||||||||||
| Sensitivity | 28.9% | 9.7% | 33.2% | 35.4% | 33.8% | 28.1% | 48.3% | |||
| Specificity | 95.5% | 95.5% | 93.0% | 93.0% | 93.0% | 93.0% | 93.0% | |||
| Predictive value positive | 97.1% | 66.7% | 91.2% | 71.9% | 71.0% | 79.1% | 60.9% | |||
| Predictive value negative | 20.6% | 52.9% | 38.9% | 73.9% | 73.5% | 57.8% | 88.8% | |||
| Threshold level = 20 ng/ml | ||||||||||
| Test positive (n/%) | 51 (14.9%) | 2 (3.2%) | 49 (17.5%) | 10 (15.4%) | 8 (12.3%) | 21 (17.4%) | 10 (34.5%) | <0.001 | 0.233 | 0.065 |
| Test negative (n/%) | 291 (85.1%) | 60 (96.8%) | 231 (82.5%) | 55 (84.6%) | 57 (87.7%) | 100 (82.6%) | 19 (65.5%) | <0.001 | 0.233 | 0.065 |
| Performance | ||||||||||
| Sensitivity | 14.9% | 3.2% | 17.5% | 15.4% | 12.3% | 17.4% | 34.5% | |||
| Specificity | 100% | 100% | 98.4% | 98.4% | 98.4% | 98.4% | 98.4% | |||
| Predictive value positive | 100% | 100% | 96.1% | 83.3% | 80.0% | 91.3% | 83.3% | |||
| Predictive value negative | 18.5% | 52.4% | 35.3% | 69.6% | 68.9% | 55.8% | 86.9% | |||
Periodontal disease, gingivitis + periodontitis.
Chi‐square tests were used to assess differences between groups.
Performance refers to distinguish periodontal disease or gingivitis from periodontal health and distinguish periodontitis (stages I to IV) from non‐periodontitis.
H, periodontal health; G, gingivitis; I, stage I periodontitis; II, stage II periodontitis; III, stage III periodontitis; IV, stage IV periodontitis; P, periodontitis; and NP, non‐periodontitis.