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. 2021 Aug 13;9:135. doi: 10.1186/s40478-021-01238-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Imaging and histopathological features of Case #8. a–e Right temporo-parietal mass, mostly tissular with central necrosis. a Peripheral cysts on T2-weighted sequence. b Cyst content isointense on FLAIR image. c Mild heterogeneous contrast enhancement on T1-weighted sequence after gadolinium injection. d Diffusion restriction. e Heterogeneous tumoral blood flow with low and intermediate flow areas on Arterial Spin Labelling perfusion imaging. f Classical ependymoma-like pattern with calcifications (HPS, magnification × 100). g Tumor with perivascular pseudorosettes (HPS, magnification × 400). h Tumor with diffuse cytoplasmic immunoexpression of GFAP (magnification × 400). i A dot-like pattern of staining for EMA in the tumor (magnification × 400). j Diffuse staining for L1CAM (magnification × 400). Black scale bars represent 250 μm (f) and 50 µm (g–j). HPS: Hematoxylin Phloxin Saffron.