Table II.
Prevalence of comorbidities among patients with different severities of atopic dermatitis
| Total |
Mild |
Moderate |
Severe |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (N = 12,780) |
(N = 9369) |
(N = 2462) |
(N = 949) |
|||||||||
| N | SPR | 95% CI | N | SPR | 95% CI | N | SPR | 95% CI | N | SPR | 95% CI | |
| Autoimmune disorders | ||||||||||||
| All | 203 | 1.59 | (1.57–1.61) | 109 | 1.34 | (1.32–1.36) | 46 | 1.46 | (1.44–1.48) | 48 | 3.31 | (3.28–3.34) |
| Rheumatoid arthritis | 92 | 1.46 | (1.43–1.49) | 53 | 1.32 | (1.30–1.35) | 22 | 1.37 | (1.34–1.39) | 17 | 2.53 | (2.50–2.57) |
| Systemic lupus erythematosus | 39 | 2.43 | (2.36–2.50) | 11 | 0.92 | (0.88–0.97) | 12 | 3.03 | (2.96–3.11) | 16 | 10.36 | (10.21–10.51) |
| Ankylosing spondylitis | 89 | 1.64 | (1.61–1.67) | 53 | 1.54 | (1.52–1.57) | 20 | 1.54 | (1.51–1.57) | 16 | 2.13 | (2.10–2.17) |
| Atopic disorders | ||||||||||||
| All | 5199 | 1.70 | (1.69–1.70) | 3788 | 1.67 | (1.67–1.68) | 989 | 1.78 | (1.77–1.78) | 422 | 2.05 | (2.04–2.05) |
| Asthma | 2538 | 1.99 | (1.98–2.00) | 1792 | 1.82 | (1.81–1.83) | 497 | 2.31 | (2.30–2.32) | 249 | 3.31 | (3.30–3.32) |
| Allergic rhinitis | 4498 | 1.72 | (1.71–1.73) | 3249 | 1.69 | (1.68–1.70) | 872 | 1.82 | (1.81–1.83) | 377 | 2.15 | (2.14–2.16) |
| Ocular disorders | ||||||||||||
| All | 4218 | 1.37 | (1.37–1.37) | 2930 | 1.35 | (1.35–1.36) | 905 | 1.44 | (1.43–1.44) | 383 | 1.48 | (1.48–1.49) |
| Conjunctivitis | 4071 | 1.39 | (1.38–1.39) | 2846 | 1.38 | (1.37–1.38) | 867 | 1.45 | (1.45–1.46) | 358 | 1.49 | (1.48–1.49) |
| Cataracts | 857 | 1.27 | (1.26–1.27) | 518 | 1.23 | (1.22–1.24) | 208 | 1.25 | (1.24–1.26) | 131 | 1.49 | (1.49–1.50) |
| Glaucoma | 238 | 1.69 | (1.67–1.71) | 143 | 1.62 | (1.60–1.64) | 56 | 1.60 | (1.58–1.62) | 39 | 2.39 | (2.36–2.41) |
| Chronic urticaria | 1751 | 3.14 | (3.12–3.15) | 975 | 2.53 | (2.52–2.55) | 507 | 3.87 | (3.86–3.89) | 269 | 5.10 | (5.09–5.12) |
| Metabolic disorders | ||||||||||||
| All | 1634 | 1.34 | (1.33–1.34) | 1017 | 1.34 | (1.33–1.34) | 422 | 1.37 | (1.36–1.38) | 195 | 1.27 | (1.26–1.27) |
| Diabetes mellitus | 942 | 1.46 | (1.45–1.47) | 578 | 1.45 | (1.44–1.46) | 243 | 1.48 | (1.47–1.48) | 121 | 1.47 | (1.47–1.48) |
| Lipid disorders | 1289 | 1.29 | (1.28–1.30) | 794 | 1.28 | (1.27–1.29) | 335 | 1.34 | (1.33–1.34) | 160 | 1.27 | (1.26–1.27) |
| Hypertensive disorders | ||||||||||||
| All | 1821 | 1.16 | (1.16–1.17) | 1121 | 1.15 | (1.15–1.16) | 470 | 1.22 | (1.22–1.23) | 230 | 1.12 | (1.12–1.13) |
| Essential hypertension | 1695 | 1.17 | (1.17–1.18) | 1044 | 1.16 | (1.16–1.17) | 435 | 1.23 | (1.23–1.24) | 216 | 1.14 | (1.13–1.14) |
| Hypertensive heart disease | 761 | 1.24 | (1.23–1.25) | 465 | 1.20 | (1.19–1.21) | 197 | 1.32 | (1.31–1.33) | 99 | 1.28 | (1.27–1.29) |
| Ischemic heart diseases | ||||||||||||
| All | 774 | 1.24 | (1.23–1.25) | 466 | 1.19 | (1.18–1.19) | 195 | 1.31 | (1.30–1.32) | 113 | 1.36 | (1.35–1.37) |
| Acute myocardial infarction | 123 | 1.33 | (1.31–1.35) | 70 | 1.21 | (1.19–1.23) | 28 | 1.34 | (1.32–1.37) | 25 | 1.77 | (1.75–1.80) |
| Angina pectoris | 246 | 1.28 | (1.26–1.30) | 147 | 1.19 | (1.18–1.21) | 60 | 1.32 | (1.30–1.33) | 39 | 1.54 | (1.52–1.56) |
| Other forms of chronic ischemic heart disease | 612 | 1.25 | (1.24–1.26) | 369 | 1.22 | (1.21–1.23) | 156 | 1.31 | (1.30–1.32) | 87 | 1.35 | (1.34–1.36) |
| Cerebrovascular disorders | ||||||||||||
| All | 354 | 1.17 | (1.16–1.18) | 219 | 1.15 | (1.13–1.16) | 87 | 1.23 | (1.21–1.24) | 48 | 1.34 | (1.33–1.35) |
| Occlusion of cerebral arteries | 286 | 1.09 | (1.07–1.10) | 178 | 1.10 | (1.08–1.11) | 67 | 1.05 | (1.03–1.06) | 41 | 1.30 | (1.29–1.32) |
| Occlusion and stenosis of precerebral arteries | 104 | 1.82 | (1.78–1.85) | 56 | 1.55 | (1.51–1.58) | 32 | 2.36 | (2.32–2.40) | 16 | 2.21 | (2.17–2.25) |
| Psychiatric disorders | ||||||||||||
| All | 1476 | 1.40 | (1.40–1.41) | 907 | 1.35 | (1.36–1.36) | 392 | 1.54 | (1.53–1.55) | 177 | 1.51 | (1.50–1.52) |
| Psychiatric disorders, including episodic mood disorders | 266 | 1.72 | (1.70–1.74) | 168 | 1.71 | (1.69–1.72) | 66 | 1.59 | (1.57–1.60) | 32 | 1.93 | (1.91–1.95) |
| Anxiety, dissociative, and somatoform disorders | 1244 | 1.44 | (1.44–1.45) | 762 | 1.39 | (1.38–1.39) | 345 | 1.64 | (1.64–1.65) | 137 | 1.37 | (1.37–1.38) |
| Nonorganic sleep disorder | 383 | 1.53 | (1.52–1.54) | 221 | 1.38 | (1.36–1.39) | 116 | 1.87 | (1.86–1.89) | 46 | 1.47 | (1.46–1.49) |
| Adjustment reaction | 83 | 1.48 | (1.45–1.51) | 54 | 1.53 | (1.50–1.56) | 16 | 1.13 | (1.11–1.16) | 13 | 2.11 | (2.07–2.14) |
| Depressive disorder | 167 | 1.60 | (1.58–1.63) | 106 | 1.61 | (1.58–1.63) | 43 | 1.70 | (1.68–1.72) | 18 | 1.52 | (1.50–1.54) |
| Attention-deficit/hyperactivity disorder | 272 | 1.11 | (1.09–1.14) | 194 | 0.96 | (0.93–0.98) | 55 | 1.67 | (1.64–1.70) | 23 | 2.18 | (2.14–2.21) |
CI, Confidence interval; SPR, standardized prevalence ratio.