Table IV.
Summary of published case series of AGEP∗
| Study | Country | No. of patients | Etiology, commonly implicated drugs (No. of patients) | Latency (Median) | Systemic involvement (No. of patients) | Treatment (No. of patients) | Outcomes |
|---|---|---|---|---|---|---|---|
| Current study | Singapore | 43 | Drugs (40) Top 3 drugs: penicillin (12), cephalosporin (4), vancomycin (4) Unknown (3) |
4.5 | Hepatocellular (2) Renal (4) |
Withdrawal of drug, topical steroids (34), systemic corticosteroids (9) | Resolution of AGEP in all patients |
| Siew et al7 (2018) | Malaysia | 21 | Drugs (21) Top 3 drugs: amoxicillin (10), cloxacillin (3), phenytoin (2) |
3.0 | Hepatocellular (3) | Withdrawal of drug, topical steroids (11), systemic corticosteroids (1), antihistamines (6) | Resolution of AGEP in all patients |
| Alniemi et al8 (2017) | USA | 28 | Drugs (26) Top 3 drugs: clindamycin (6), amoxicillin (3), cephalexin (2), cefepime (2), diltiazem (2) Unknown (2) |
8.3 | Hepatocellular (19), Renal (9), Pulmonary (7), Hemodynamic instability (2) |
Withdrawal of drug (23), systemic corticosteroids (11), topical therapies (26), antihistamines (14) | Resolution of AGEP in all patients |
| Thienvibul et al9 (2015) | Thailand | 19 | Drugs (18) Top 3 drugs: neta-lactams (8), carbapenem (3), cephalosporin (3) Viral infection (1) |
3.0 | Hepatocellular (5) | Topical corticosteroid (11), oral prednisolone (6), supportive care (2) | Resolution of AGEP in all patients |
| Hotz et al4 (2013) | France | 58 | Drugs (57) Top 3 drugs: amoxicillin (11), amoxicillin-clavulanic acid (3), pristinamycin (8) Unknown (1) |
4.5 | Renal (6), Hepatocellular (7), Pulmonary (2), Bone marrow (1) |
Withdrawal of drug, topical corticosteroids (58). No systemic corticosteroid used. |
Resolution of AGEP in all patients |
| Choi et al5 (2010) | Korea | 36 | Drug (23) Top 3 drugs: amoxicillin (6), herbal medicine (4), lacquer (3), iopamidol (2) Unknown (13) |
9.5 | NA | Oral or intravenous steroid (24), oral antihistamines (9), topical steroids (1) 2 patients were not treated |
Resolution of AGEP in all patients |
| Chang et al10 (2008) | Taiwan | 16 | Drug (10) Top 3 drugs: beta-lactams (5), antiepileptics (2), quinolones (2) Infection (4), contact history with scabies (1), unknown (1) |
2.7 | NA | IV hydrocortisone (8), topical corticosteroids (2), oral corticosteroid (5), antihistamine (1) | Resolution of AGEP in all patients |
| Sidoroff et al (2007)1 | Multinational | 97 | Drugs (97) Top 3 drugs: pristinamycin (10), aminopenicillins (18), quinolones (9) |
NR | NR | NR | NR |
| Roujeau et al (1991)6 | France | 63 | Drugs (55): Top 3 drugs: amoxicillin (18), ampicillin (5), pristinamycin (4), Mercury (8), viral infection (4), Unknown (3) |
5 | Renal (15) | NR | Resolution of AGEP in all patients |
AGEP, Acute generalized exanthematous pustulosis; IV, intravenous; NR, not reported.
∗
Restricted to case series with a sample size >10.