Table I.
Outcomes of first-line treatments used for prurigo pigmentosa
| Treatment class | Treatment | No. of times reported | Resolution NR (No. of times) | No resolution (No. of times) | Partial resolution (No. of times) | Complete resolution (No. of times) | Average resolution period (days)∗ | Recurrence NR (No. of times) | No recurrence (No. of times) | Recurrence occurred (No. of times) |
|---|---|---|---|---|---|---|---|---|---|---|
| Tetracycline monotherapy | Minocycline | 77 | 33 | 2 | 7 | 35 | 34.5 | 47 | 23 | 7 |
| Doxycycline | 56 | 1 | 1 | 25 | 29 | 23.4 | 6 | 44 | 6 | |
| Tetracycline† | 6 | - | - | 6 | - | - | - | 5 | 1 | |
| Total | 139 | 34 | 3 | 38 | 64 | 53 | 72 | 14 | ||
| Tetracyclines and dietary changes | Minocycline and diet | 6 | 0 | - | 2 | 4 | 26.0 | 3 | 3 | - |
| Doxycycline and diet | 5 | - | - | - | 5 | 48.5 | - | 4 | 1 | |
| Total | 11 | 0 | - | 2 | 9 | 3 | 7 | 1 | ||
| Tetracycline combination therapies | Minocycline and TCS | 24 | 15 | - | 6 | 3 | 33.3 | 17 | 7 | - |
| Minocycline and antihistamines | 3 | 3 | - | - | - | - | 3 | - | - | |
| Minocycline and antihistamines and TCS | 2 | - | - | 2 | - | 10.5 | - | 2 | - | |
| Doxycycline and antihistamine and SCS | 3 | 3 | - | - | - | - | 3 | - | - | |
| Doxycycline and dapsone | 2 | - | - | 2 | - | 14.0 | 1 | 1 | - | |
| Doxycycline followed by minocycline | 2 | - | - | 2 | - | - | - | 2 | - | |
| Total | 36 | 21 | - | 12 | 3 | 24 | 12 | - | ||
| Topical corticosteroids | TCS monotherapy | 4 | 1 | 1 | 2 | - | 127.0 | 1 | 1 | 2 |
| TCS and antihistamines | 4 | 3 | - | 1 | - | 180 | 3 | 1 | - | |
| SCS | 4 | - | - | 2 | 2 | 19.5 | 3 | 1 | - | |
| Total | 12 | 4 | 1 | 5 | 2 | 7 | 3 | 2 | ||
| Dapsone | Dapsone monotherapy | 20 | 12 | - | 1 | 7 | 14.4 | 17 | 1 | 2 |
| Total | 20 | 12 | - | 1 | 7 | 17 | 1 | 2 | ||
| Antibiotics monotherapy | Roxithromycin | 2 | - | - | - | 2 | 7.5 | - | 2 | - |
| Sulfisomezole | 2 | - | - | - | 2 | 10.5 | - | - | 2 | |
| Clarithromycin | 2 | - | - | - | 2 | 7.0 | - | 2 | - | |
| Total | 6 | - | - | - | 6 | - | 4 | 2 | ||
| Retinoid monotherapy | Oral isotretinoin | 2 | - | - | - | 2 | 90.0 | - | 1 | 1 |
| Total | 2 | - | - | - | 2 | - | 1 | 1 | ||
| Conservative or no treatment | Changing diet | 12 | - | - | 7 | 5 | 30.0 | 7 | 5 | - |
| Insulin (patients with DM) | 6 | - | - | 1 | 5 | 16.5 | 4 | 2 | - | |
| Self-resolving | 6 | - | - | 1 | 5 | 71.0 | 2 | 4 | - | |
| Total | 24 | - | - | 9 | 15 | 13 | 11 | - |
- (hyphen), 0; DM, diabetes mellitus; No., number; NR, not reported; SCS, systemic corticosteroids; TCS, topical corticosteroids.
∗
Average time in days to reach partial or complete resolution after starting treatment.
†
Specifics not reported.