Table XI.
Reason for treatment discontinuation due to side effects∗
| Type of side effect | Number (%) of discontinued treatments∗ (per total number of stopped treatments†/per total treatments‡) |
|---|---|
| Depression | 11 (5.6/2.9) |
| Gastrointestinal symptoms | 32 (16.3/8.7) |
| Headache | 8 (4.1/2.1) |
| Infection | 4 (2.0/1.1) |
| Liver toxicity | 1 (0.5/0.3) |
| Kidney toxicity | 1 (0.5/0.3) |
| Neurological symptoms | 2 (1.0/0.5) |
| Sleep disorder | 2 (1.0/0.5) |
| Rash | 1 (0.5/0.3) |
| Skin cancer | 1 (0.5/0.3) |
| Other cancer | 1 (0.5/0.3) |
| Other | 5 (2.5/1.3) |
∗
Number of patients (N = 61) who discontinued apremilast due to side effects (N = 69).
†
Total number of stopped treatments (N = 195).
‡
Total number of patients and treatments (N = 367). Note that treatment was stopped due to 2 side effects in 6 patients and due to 3 side effects in 1 patient.