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. 2021 Jul 30;12:706136. doi: 10.3389/fimmu.2021.706136

Figure 3.

Figure 3

The landscape of presentation shapes different CD4+ subpopulations according to their CDR3 physicochemical properties and specificity. Possible shifts in pMHC spectra can contribute to transdifferentiation between some subpopulations of CD4+ T cells. The width of the arrows reflects the number of common TCR clonotypes between subpopulations.