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. 2021 Jul 30;11:624837. doi: 10.3389/fonc.2021.624837

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Copyright © 2021 Hua, Li, Liu, Shen, Zhu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KLK8 was associated with PDAC tumorigenesis and prognosis in the TCGA-PAAD cohort. (A) KLK8 expression in different cancers and their paired normal tissues in the GEPIA. The height of bar represents the median expression of certain tumor type or normal tissue. (B) KLK8 expression of normal specimens and pancreatic carcinoma from an independent pancreatic dataset in the Oncomine database. The expression fold-change was 2.332. (C) In the TCGA-PAAD cohort, KLK8 was more significantly expressed in cancer patients (n=178) than in normal controls (n =171). (D) The TCGA-PAAD database has 178 pancreatic cancer samples, including 8 pancreatic neuroendocrine tumor (NET) samples. Overall survival (OS, left panel) and Disease-free survival (DFS, right panel) were compared between patients with low and high KLK8 expression in the TCGA-PAAD cohort (n=178). (E) We deleted these 8 NETs, and the remaining cohort consisted of 170 primary PDACs samples (TCGA-PAAD cohort without NETs, n=170) were used for performing the survival analysis. OS (left panel) and DFS (right panel) was compared between patients with low and high KLK8 expression. ****p < 0.0001 vs normal.