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. 2021 Jul 30;11:624837. doi: 10.3389/fonc.2021.624837

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Copyright © 2021 Hua, Li, Liu, Shen, Zhu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significantly-altered pathways were predicted in PDAC and verified in KLK8-overexpressed pancreatic cancer cells. (A) Gene sets enriched in the transcriptional profiles of tumors belonging to the top KLK8 high-expression group, compared with the bottom-expression group in the TCGA dataset. Shown are the NES (normalized enrichment score) values for each pathway using the Hallmark gene sets. The functional annotations of KLK8 positive and negative expression in PDAC was predicted. A nominal p value of <0.05 is considered statistically significant. (B, C) GSEA highlighted positive association of increased KLK8 expression levels with PI3K-Akt-mTOR (B) and Notch (C) signal pathways. (D) levels of key proteins in PI3K-AKT-mTOR and Notch signaling pathways were examined in KLK8-overexpressed Mia-paca-2 and Panc-1 cells using western blot. NES = normalized enrichment score. (n=3).