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KLK8 decreased protein levels of pro-apoptotic proteins through the activation of PI3K-Akt-mTOR pathway. Mia-paca-2 and Panc-1 cells in Lv-KLK8 (A) and Lv-Control (B) were treated with PI3K inhibitor LY294002(75 μM), Akt inhibitor Deguelin (500 nM), mTOR inhibitor Rapamycin (100 nM) or Notch inhibitor RO4929097 (10 μM). (A, B) protein levels of pro-apoptotic markers cleaved caspase-3, cleaved caspase-9 and Bax were assessed by western blot.
