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Representative in vivo stereomicroscopic images revealing the corneal health in the naïve (n = 6) and AAV5–Dcn delivered (n = 6) rabbit eyes. (A and B), (C and D), (E and F), and (G and H) represent the images of before gene delivery, after 1 month, 3 months, and 6 months of gene delivery, respectively. AAV5–Dcn gene therapy caused no long-term toxicity to the cornea (P > 0.05). Naked vector-treated rabbit eyes (n = 6) showed images similar to AAV5–Dcn (not shown). Scale bar = 2.0 mm.
