Table 2.

Summary of Clinical Findings and Histopathology in Rabbit Eyes Subconjunctivally Injected with Varying Doses of Human and Rabbit MSCs

		Clinical Findings			Histopathology
		Week 1 to 6		Week 7 to 12
	Rabbit #	Cornea (Epithelial Defect, Scarring, Opacity/Neovascularization)	Conjunctiva (Scarring, Redness/Swelling)	Cornea (Epithelial Defect, Scarring, Opacity/Neovascularization)	Conjunctiva (Scarring, Redness/Swelling)	Cornea	Conjunctiva	Post. Segment and Other Structures
1 million rabbit BM-MSC	1902	Normal	Normal	Normal	Normal	Normal	+ 1/2 Inflammation	Normal
	1903	Normal	Normal	Normal	Normal	Normal	Normal	Normal
	1905	Normal	Normal	Normal	Normal	Normal	Normal	Normal
3 million rabbit BM-MSC	1907	Normal	Normal	Normal	Normal	Normal	Normal	Normal
	1908	Normal	Normal	Normal	Normal	Normal	Normal	Normal
	4441	Normal	Normal	Normal	Normal	Normal	Normal	Normal
6 million rabbit BM-MSC	4442	Normal	Normal	Normal	Normal	Normal	Normal	Normal
	4443	Normal	Mild redness	Normal	Normal	Normal	Normal	Normal
	4444	Normal	Mild swelling/redness	Normal	Normal	Normal	Normal	Normal
1 million human BM-MSC	1904	Normal	Normal	Normal	Normal	Normal	Normal	Normal
	1906	Normal	Normal	Normal	Normal	Normal	+1 Inflammation	Normal
	1909	Normal	Mild redness	Normal	Normal	Normal	+ 1/2 Inflammation	Normal
3 million human BM-MSC	1910	Normal	Mild swelling/redness	Normal	Normal	Normal	+ 1/2 Inflammation	Normal
	1911	Normal	Mild swelling/redness	Normal	Normal	Normal	Normal	Normal
	4437	Normal	Mild swelling/redness	Normal	Normal	Normal	+1/4 Inflammation	Normal
6 million human BM-MSC	4436	Normal	Mild swelling/redness	Normal	Normal	Normal	Normal	Normal
	4439	Normal	Mild swelling/redness	Normal	Normal	Normal	Normal	Normal
	4440	Normal	Normal	Normal	Normal	Normal	Normal	Normal

BM, bone marrow.