Table 1.
Comparison of GABAergic clusters with high Pcdh19 expression in mouse and human sSC
| Mouse Whole Cortex & Hippocampus - SMART-SEQ (2019) with 10×-Smart-Seq Taxonomy (2020) |
Mouse V1 & ALM - SMART- SEQ (2018) |
Homologous cell type taxonomy (Hodge et al., 2019) |
Human MTG - SMART-SEQ (2018) |
Human MULTIPLE CORTICAL AREAS - SMART-SEQ (2019) |
|---|---|---|---|---|
| 3_Lamp5 Lhx6 (H) | Lamp5 Lhx6 | Lamp5 Lhx6 | Inh L2-5 LAMP5 CA1 | Inh L1-6 LAMP5 CA13 (H) Inh L5-6 LAMP5 SFTA3 (H) |
| 25_Sncg (M-H) 35_Sncg (H) |
Sncg Vip Nptx2 Sncg Gpr50 Sncg Vip Itih5 |
Vip Sncg | Inh L1-2 VIP TSPAN12 | Inh L1 VIP PRSS8 (L) |
| 40-41_Vip (L) 44-47_Vip (L) |
Serpinf Aqp5 Vip Vip Pygm C1ql1 Vip Chat Htr1f |
Vip 3 | Inh L1-2 VIP PCDH20 | Inh L1-2 VIP PPAPDC1A (H) |
| 47_Vip (H) | Vip Rspo4 Rxfp1 Chat Vip Rspo1 Itga4 |
Vip 4 | Inh L2-4 VIP CBLN1 Inh L1-3 VIP CCDC184 Inh L1-3 VIP GGH Inh L1-3 VIP CHRM2 |
Inh L3 VIP CBLN1 (L) Inh L1-3 VIP ACHE (M) Inh L1-3 VIP GGH (H) Inh L1-2 VIP ZNF322P1 (H) |
| 51_Vip (H) | Vip Gpc3 Slc18a3 | Vip 2 | Inh L2-6 VIP QPCT Inh L3-6 VIP HS3ST3A1 |
Inh L1-6 VIP RGS16 (H) Inh L2-6 VIP VIP (H) Inh L3-6 VIP KCTD13 (H) |
| 59_Vip (H) | Vip Igfbp6 Car10 | Vip 1 | Inh L1-4 VIP PENK Inh L1-3 VIP ADAMTSL1 Inh L1-2 SST BAGE2 |
Inh L1-6 VIP PENK (H) Inh L1-5 VIP KCNJ2 (H) Inh L1 VIP CXCL14 (L) Inh L1 ADARB2 DISP2 (H) |
| 61_Sst Chodl (H) | Sst Chodl | Sst Chodl | Inh L3-6 SST NPY | Inh L6 SST NPY (M) |
| 64_Sst (L) 66_Sst (N.P.) 67_Sst (L) 79_Sst (L) 80-82_Sst (M) |
Sst Myh8 Fibin Sst Chrna2 Glra3 Sst Myh8 Etv1 Sst Nr2f2 Necab1 Sst Chrna2 Ptgdr |
Sst 1 | Inh L3-6 SST HPGD Inh L4-6 SST B3GAT2 |
Inh L4-6 SST MTHFD2P6 (M) |
| 70_Sst (H) 72_Sst (H) 73_Sst (H) 78_Sst (H) |
Sst Tac2 Tacstd2 Sst Rxfp1 Eya1 Sst Rxfp1 Prdm8 |
Sst 3 | Inh L4-6 SST GXYLT2 Inh L5-6 SST NPM1P10 |
Inh L5-6 SST KLHL14 (L) Inh L5-6 SST ISOC1 (L) |
| 84_Sst (H) | Sst Esm1 | Sst 2 | Inh L5-6 SST KLHDC8A (only 3 cells) |
no equivalent |
| 90_Sst (H) 92_Sst (H) 94_Sst (H) 95_Sst (H) |
Sst Calb2 Pdlim5 Sst Tac1 Tacr3 Sst Calb2 Necab1 Sst Tac1 Htr1d |
Sst 5 | Inh L1-3 SST CALB1 | Inh L3-5 SST MAFB (M) |
| 111_Pvalb (H) | Pvalb Akr1c18 Ntf3 | Pvalb 1 | Inh L5-6 PVALB LGR5 Inh L5-6 SST TH Inh L4-5 PVALB MEPE Inh L5-6 SST MIR548F2 |
Inh L5-6 PVALB FAM150B (M) Inh L5-6 SST TH (M) Inh L5 PVALB CNTNAP3P2 (M) Inh L5-6 PVALB STON2 (M) |
| Pvalb Sema3e Kank4 Palb Calb1 Sst |
Pvalb 2 | Inh L2-4 PVALB WFDC2 Inh L4-6 PVALB SULF1 |
Inh L2-4 PVALB C8ORF4 (M) Inh L5 PVALB CNTNAP3P2 (M) Inh L1-3 PVALB WFDC2 (H) Inh L3-4 PVALB HOMER3 (L) |
|
| 112_Pvalb (H) | Pvalb Gpr149 Islr | Pvalb 1 | Inh L5-6 PVALB LGR5 Inh L5-6 SST TH Inh L4-5 PVALB MEPE Inh L5-6 SST MIR548F2 |
Inh L5-6 PVALB FAM150B (M) Inh L5-6 SST TH (M) Inh L5 PVALB CNTNAP3P2 (M) Inh L5-6 PVALB STON2 (M) |
| 113_Pvalb (H) 114_Pvalb (M) 115_Pvalb (H) |
Pvalb Tpbg Pvalb Reln Tac1 Pvalb Reln Itm2a |
Pvalb 2 | Inh L2-4 PVALB WFDC2 Inh L4-6 PVALB SULF1 |
Inh L2-4 PVALB C8ORF4 (M) Inh L5 PVALB CNTNAP3P2 (M) Inh L1-3 PVALB WFDC2 (H) Inh L3-4 PVALB HOMER3 (L) |
| 116_Pvalb (H) | Sst Tac1 Tacr3 Sst Tac1 Htr1d |
Sst 5 | Inh L1-3 SST CALB1 | Inh L3-5 SST MAFB (M) |
| Palb Calb1 Sst Pvalb Tpbg |
Pvalb 2 | Inh L2-4 PVALB WFDC2 Inh L4-6 PVALB SULF1 |
Inh L2-4 PVALB C8ORF4 (M) Inh L5 PVALB CNTNAP3P2 (M) Inh L1-3 PVALB WFDC2 (H) Inh L3-4 PVALB HOMER3 (L) |
|
| 119_Pvalb (H) | Pvalb Vipr2 | Chandelier | Inh L2-5 PVALB SCUBE3 | Inh L1-6 PVALB SCUBE3 (H) |
GABAergic clusters with high Pcdh19 expression in the sSC from either the mouse “Whole Cortex & Hippocampus - SMART-SEQ (2019) with 10×-Smart-Seq taxonomy (2020)” dataset or the human “Multiple Cortical Areas – SMART-SEQ (2019)” dataset are listed in the left and right columns of the table, respectively. The middle columns list the clusters and homologous cell type taxonomy groups that have allowed the indirect correlation between them. H, High expression; M, medium expression; L, low expression; N.P., cluster is not present in the sSC.