Figure 3.

At 14 months of nusinersen treatment, CMAP decrement was not associated with age or disease duration and was similar when stratified by ambulatory ability. CMAP decrement was not associated with (A) age (r²=0.0256, p=0.9364, n=15) or (B) disease duration (r²=0.03323, p=0.5328, n=14). (C) When stratified by ambulatory ability, CMAP decrement was not significantly different in ambulatory (−11.8%±9.5%, n=9) versus non-ambulatory (11.9%±7.0%, n=6) participants following 14 months of nusinersen treatment (unpaired t-test, p=0.9943). CMAP decrement for analyses obtained in participants at 14 months of nusinersen. R² is the square of Pearson correlation coefficients. CMAP, compound muscle action potential.