Table 3.
Differences between serum FA concentrations [mg/l] in psoriatic patients with ALT serum concentration within normal range and with ALT above the limit, and the control group. Data are shown as median and quartiles (Q1 first quartile, Q3 third quartile). Significant differences between the psoriatic patients and the control group are shown as: *p < 0.05; **p < 0.01; ***p < 0.001
| Fatty acid | Psoriasis normal ALT (n = 73) |
Psoriasis ALT above the limit (n = 12) |
Control (n = 32) |
|---|---|---|---|
| Myristic (14:0) | 25.8 (20.4–40.3) | 28.7 (26.4–37.1) | 34.8 (23.5–56.5) |
| Palmitic (16:0) | 802.2 (716.1–991.6) | 871.3 (743.9–1018.2) | 755.9 (707.9–959.2) |
| Palmitoleic (16:1n-7) | 100.6 (74.0–154.0)** p = 0.009 |
124.5 (95.4–140.9)* p = 0.013 |
75.7 (55.4–101.6) |
| Stearic (18:0) | 234.5 (200.7–271.8) | 253.4 (224.0–303.8) | 250.5 (233.2–278.4) |
| Oleic (18:1n9c) | 827.4 (741.6–1045.5) | 906.8 (776.1–1140.8) | 787.1 (702.8–881.4) |
| Linoleic (18:2n-6) | 971.9 (840.5–1091.9)*** p < 0.001 |
956.4 (915.2–1028.2)* p = 0.033 |
1102.5 (1013.5–1229.9) |
| Arachidic (20:0) | 7.6 (6.5–8.8)*** p < 0.001 |
7.5 (6.4–9.0)** p = 0.002 |
9.9 (8.1–11.5) |
| α-Linolenic (18:3n-3) | 20.5 (16.0–27.2)*** p < 0.001 |
21.3 (19.3–24.1)* p = 0.043 |
29.8 (23.1–37.1) |
| Behenic (22:0) | 15.4 (13.4–18.0)*** p < 0.001 |
14.5 (13.7–17.7)** p = 0.005 |
19.5 (16.9–22.5) |
| Arachidonic (20:4n-6) | 253.6 (216.1–299.6) | 253.2 (216.4–282.8) | 285.7 (243.5–315.2) |
| Lignoceric (24:0) | 10.7 (9.2–12.3)*** p < 0.001 |
10.3 (7.9–13.2)*** p = 0.001 |
14.2 (12.1–17.0) |
| Eicosapentaenoic (20:5n-3) | 32.0 (22.8–45.9)** p = 0.002 |
33.6 (21.6–51.6) | 48.0 (36.4–63.4) |
| Nervonic (24:1n-9) | 42.6 (36.7–48.8) | 43.5 (40.9–51.1) | 45.0 (41.6–50.8) |
| Docosahexaenoic (22:6n-3) | 70.5 (54.3–87.8) | 63.8 (47.2–92.4) | 80.8 (67.6–89.9) |
| Total FA | 3455.8 (3093–4021.3) | 3659.7 (3267.9–4141.1) | 3556.1 (3250.8–4147.2) |
| n-3 PUFA | 125.4 (96.5–156.6)** p = 0.003 |
111.9 (107.9–158.8) | 158.7 (135.7–185.7) |
| n-6 PUFA | 1244.5 (1065.1–1371.1)*** p < 0.001 |
1231.0 (1153.6–1294.3)* p = 0.016 |
1411.3 (1264.9–1529.1) |
| n-6/n-3 ratio | 10.1 (7.9–11.8) | 10.4 (8.2–11.7) | 9.1 (7.2–10.4) |
| %SFA | 32.1 (31.4–33.1) | 32.7 (31.7–34.6) | 31.3 (30.0–32.8) |
| %MUFA | 29.0 (26.7–31.8)*** p < 0.001 |
29.8 (28.7–31.9)*** p < 0.001 |
25.5 (23.4–27.1) |
| %PUFA | 38.8 (35.2–41.6)*** p < 0.001 |
37.8 (33.6–39.6)*** p < 0.001 |
43.2 (40.6–45.7) |
| SFA/UFA | 0.47 (0.46–0.49) | 0.48 (0.46–0.53) | 0.45 (0.43–0.49) |