Table 6.
Causes for hospital admission after lung transplant.
| Patient | Family aggregation | Percentile telomere length | Likely causal gene(s) | Hospital admissions after transplant | Infectious cause | Other causes |
|---|---|---|---|---|---|---|
| PATIENTS WITHOUT TELOMERE SHORTENING | ||||||
| 1 | Yes | 75–50th | Not tested | 1 | Urinary sepsis | None |
| 2 | No | 50–25th | Not tested | 1 | Lower right lobe pneumonia (P. aeruginosa) | None |
| 3 | No | 50–25th | Not tested | 1 | Respiratory infection (Rhinovirus) | CLAD |
| PATIENTS WITH TELOMERE SHORTENING | ||||||
| 4 | No | <25th | TERT | 1 | None | Cervical lymphadenectomy (M1 squamous cell carcinoma of unknown primary origin) |
| 5 | Yes | <25th | TERT | 3 | Respiratory infection (MRSA) Empyema (S.aureus) |
Suspected unconfirmed CLAD |
| 6 | No | <25th | RTEL1 | 3 | Acute gastroenteritis Elbow abscess Influenza A virus infection |
None |
| 7 | Yes | <25th | DKC1 | 3 | CMV viremia Lower right lobe pneumonia + non-complicated parapneumonic pleural effusion |
Fever of unknown origin |
| 8 | No | <10th | RTEL1 | 1 | None | CLAD |
| 9 | No | <10th | Not found | 2 | None | Pulmonary embolism Cervix squamous cell carcinoma stage IIIB |
| 10 | No | <10th | RTEL1 | 3 | Respiratory infection (Respiratory syncytial virus) Bacteremia (P.aeruginosa) Influenza b virus infection |
None |
| 11 | No | <1th | DKC1 | 6 | Respiratory infection (x2) Perianal condylomatosis |
Acute ILD exacerbation in native lung ILD progression in native lung (X2) |
| 12 | Yes | <1th | Not found | 1 | Cavitated pneumonia (P.aeruginosa) + bacteriemia (P.aeruginosa) | None |