Table 3.
Subcategory Breakdown of Selected SDOCT Findings in 2-, 3-, and 4-year Precursor Regions of New Onset Geographic Atrophy
| 4 Year Precursor Regions | 3 Year Precursor Regions | 2 Year Precursor Regions | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GA Regionsa | Control Regionsa | p-valueb | GA Regionsa | Control Regionsa | p-valueb | GA Regionsa | Control Regionsa | p-valueb | |
| Proportion (%) | Proportion (%) | Proportion (%) | Proportion (%) | Proportion (%) | Proportion (%) | ||||
| Subretinal lesion | 4/25 (16.00) | 5/25 (20.00) | 0.6547 | 6/33 (18.18) | 10/33 (30.30) | 0.1025 | 5/54 (9.26) | 15/54 (27.78) | 0.0039 |
| a. SHRM | 0/4 (0.00) | 0/5 (0.00) | ----- | 1/6 (14.29) | 0/10 (0.00) | ----- | 1/5 (20.00) | 1/15 (6.67) | ----- |
| b. Hemorrhage | 0/4 (0.00) | 0/5 (0.00) | ----- | 0/6 (0.00) | 0/10 (0.00) | ----- | 1/5 (20.00) | 0/15 (0.00) | ----- |
| c. Subretinal Drusenoid Deposit | 4/4 (100.00) | 5/5 (100.00) | ----- | 3/6 (42.86) | 10/10 (100.00) | ----- | 4/5 (80.00) | 14/15 (93.33) | ----- |
| d. Vitelliform | 0/4 (0.00) | 0/5 (0.00) | ----- | 2/6 (28.57) | 0/10 (0.00) | ----- | 0/5 (0.00) | 0/15 (0.00) | ----- |
| e. Retinal Angiomatous Proliferation (Type 3 Macular Neovascularization) | 0/4 (0.00) | 0/5 (0.00) | ----- | 0/6 (0.00) | 0/10 (0.00) | ----- | 0/5 (0.00) | 0/15 (0.00) | ----- |
| RPE Elevation | 25/25 (100.00) | 21/25 (84.00) | ----- | 32/33 (96.97) | 28/33 (84.85) | 0.0455 | 54/54 (100.00) | 44/54 (81.48) | ----- |
| a. Drusen | 25/25 (100.00) | 21/21 (100.00) | ----- | 31/32 (96.88) | 28/28 (100.00) | ----- | 54/54 (100.00) | 44/44 (100.00) | ----- |
| b. PED | 0/25 (0.00) | 0/21 (0.00) | ----- | 4/32 (12.50) | 1/28 (3.57) | ----- | 5/54 (9.26) | 1/44 (2.27) | ----- |
| b1. PED fluid component | 0/0 (--) | 0/0 (--) | ----- | 1/4 (25.00) | 0/1 (0.00) | ----- | 1/5 (20.00) | 0/1 (0.00) | ----- |
Note: Regions could contain more than one subcategory of features.
a
GA and Control Regions of Interest (ROIs) were identified at GA incident year.
b
Wilcoxon Signed Rank and Bowker’s tests for matched pairs with alpha value = 0.05; “-“ indicates test could not be carried out due to asymmetry. Matched pairs statistical analysis could not be carried out for outcome subcategories due to asymmetrical dataset. The p-values refer to paired data rather than a comparison of the 2 means reported in the columns to the left of the p-value.