Table 4.
Analysis of selected SDOCT findings additionally scored on categorical scales at 2-, 3-, and 4-years prior to new onset of geographic atrophy
| 4 Year Precursor Regions | 3 Year Precursor Regions | 2 Year Precursor Regions | ||||
|---|---|---|---|---|---|---|
| GA Regionsa | Control Regionsa | GA Regionsa | Control Regionsa | GA Regionsa | Control Regionsa | |
| Number of ROIsb | 25 | 25 | 33 | 33 | 54 | 54 |
| % (Number) | % (Number) | % (Number) | % (Number) | % (Number) | % (Number) | |
| Photoreceptor Zone Thinning c | ||||||
| No thinning = 0 | 52 (13) | 92 (23) | (45) 15 | 73 (24) | 33 (18) | 76 (41) |
| 25% thinning = 1 | 12 (3) | 4 (1) | 18 (6) | 21 (7) | 19 (10) | 20 (11) |
| 50% thinning = 2 | 24 (6) | 4 (1) | 15 (5) | 6 (2) | 26 (14) | 4 (2) |
| 100% thinning = 4 | 12 (3) | 0 (0) | 21 (7) | 0 (0) | 22 (12) | 0 (0) |
| RPE Layer Loss | ||||||
| Intact = 0 | 24 (6) | 48 (12) | 18 (6) | 58 (19) | 2 (1) | 57 (31) |
| Disrupted = 1 | 60 (15) | 52 (13) | 61 (20) | 30 (10) | 59 (32) | 41 (22) |
| Absent = 2 | 16 (4) | 0 (0) | 21 (7) | 12 (4) | 39 (21) | 2 (1) |
| Hypertransmission | ||||||
| 0% increase =0 | 48 (12) | 64 (16) | 52 (17) | 76 (25) | 31 (17) | 80 (43) |
| 50% increase = 1 | 40 (10) | 36 (9) | 27 (9) | 21 (7) | 56 (30) | 20 (11) |
| 100% increase = 2 | 12 (3) | 0 (0) | 21 (7) | 3 (1) | 13 (7) | 0 (0) |
a
GA and Control Regions of Interest (ROIs) were identified at GA incident year.
b
ROIs in each precursor year are a subset of the 62 incident GA ROIs, not a subset of the adjacent precursor year
c
Photoreceptor zone thinning was measured by degree of outer plexiform layer dipping towards the RPE.