. Author manuscript; available in PMC: 2021 Dec 1.

Published in final edited form as: Alzheimers Dement. 2020 Dec 7;16(Suppl 2):e043533. doi: 10.1002/alz.043533

Table 1.

Demographics of subjects carrying or not carrying APOE ε4 allele across ROSMAP, LBB and MSBB

	ROSMAP			LBB			MSBB
	ε4+	ε4−	P	ε4+	ε4−	P	ε4+	ε4−	P
N^#	158	414		36	32		41	88
Age at death^*	87.31 (6.01)	88.70 (6.65)	0.02	84.58 (9.00)	84.72 (10.13)	0.95	86.27 (7.22)	85.33 (7.80)	0.5
Female^$	93 (59%)	268 (65%)	0.23	25 (69%)	21 (66%)	0.94	27 (66%)	53 (60%)	0.68
AD cases^$	128 (81%)	221 (53%)	2.48x10⁻⁹	33 (92%)	19 (59%)	0.004	34 (83%)	40 (45%)	0.0001
pTAU (sqrt)^*	2.75 (1.67)	1.92 (1.16)	2.61x10⁻⁸	NA	NA	NA	NA	NA	NA
NP^*	1.20 (0.92)	0.64 (0.73)	5.60x10⁻¹¹	NA	NA	NA	NA	NA	NA

N represent the total number of subjects with measurements of any of the pathological traits listed in the table.

represent the mean and standard deviation of each trait in subgroups of subjects carrying or not carrying APOE4 allele and the P values of their differences using t test.

represent the count and percentage of each trait in subgroups of subjects carrying or not carrying APOE4 allele and the P values of their differences using chi-square test.

Abbreviations: pTAU, abnormally phosphorylated Tau protein, AT8.