Table 1.

Average PSNR and average SSIM of the seven different SR methods over all regular-microscopy and mini-microscopy images showing in Fig. 3.

Regular-microscopy Images
Metrics╲Methods	Bicubic [17]	EDSR [39]	FALSR [40]	DPSZ [41]	SRGAN [28]	ESRGAN [9]	ESRGAN*
Average PSNR	28.15	30.69	29.90	28.48	27.38	26.39	31.03
Average SSIM	0.80	0.86	0.86	0.81	0.77	0.73	0.88
Mini-microscopy images
Metrics╲Methods	Bicubic [17]	EDSR [39]	FALSR [40]	DPSZ [41]	SRGAN [28]	ESRGAN [9]	ESRGAN*
Average PSNR	33.64	35.37	33.99	32.98	29.20	33.83	35.85
Average SSIM	0.81	0.84	0.84	0.80	0.81	0.82	0.85

This experiment followed the setup and used the same metrics as comparisons on regular-microscopy images shown in Fig. 2. A higher PSNR and a higher SSIM generally indicate that the reconstruction is of higher quality. Our ESRGAN* outperformed alternative state-of-the-art approaches. The first, second, and third best are identified with red, blue, and green, respectively.