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. 2021 Aug 13;16(8):e0256205. doi: 10.1371/journal.pone.0256205

Table 2. Relationship of lymphopenia according to Major Diagnostic Categories (MDC) (n = 58,260).

Cases Lymphopenia OR (CI 95%) Sig. p
n = 23,892 (41.0%)
n n (%)
01 - Nervous System 3,823 954 (25.0) 0.46 (0.42–0.49) < 0.001
02 - Eye 216 30 (13.9) 0.23 (0.16–0.34) < 0.001
03 - Ear, Nose, Mouth and Throat 965 411 (42.6) 1.07 (0.94–1.22) NS
04 - Respiratory System 10,530 5,658 (53.7) 1.88 (1.80–1.96) < 0.001
05 - Circulatory System 8,868 3,003 (33.9) 0.70 (0.67–0.73) < 0.001
06 - Digestive System 7,461 2,952 (39.6) 0.93 (0.89–0.98) 0.007
07 - Hepatobiliary System and Pancreas 3,311 1,685 (50.9) 1.53 (1.42–1.64) < 0.001
08 - Musculoskeletal System and Connective Tissue 5,950 2,725 (45.8) 1.24 (1.18–1.31) < 0.001
09 - Skin, Subcutaneous Tissue and Breast 1,006 320 (31.8) 0.67 (0.58–0.76) < 0.001
10 - Endocrine, Nutritional and Metabolic System 1,312 463 (35.3) 0.78 (0.70–0.86) < 0.001
11 - Kidney and Urinary Tract 5,293 2,285 (43.2) 1.10 (1.04–1.17) 0.001
12 - Male Reproductive System 749 262 (35.0) 0.77 (0.66–0.90) 0.001
13 - Female Reproductive System 1,341 246 (18.3) 0.32 (0.28–0.36) < 0.001
14 - Pregnancy, Childbirth and Puerperium 9 2 (22.2) 0.41 (0.85–1.98) NS
16 - Blood and Blood Forming Organs and Immunological Disorders 946 529 (55.9) 1.84 (1.62–2.10) < 0.001
17 - Myeloproliferative Diseases (Poorly Differentiated Neoplasms) 863 540 (62.6) 2.44 (2.10–2.80) < 0.001
18 - Infectious and Parasitic Diseases 1,575 1,031 (65.5) 2.80 (2.52–3.12) < 0.001
19 - Mental 1,652 162 (9.8) 0.15 (0.13–0.18) < 0.001
20 - Alcohol/Drug Use or Induced Mental Disorders 927 75 (8.1) 0.12 (0.10–0.16) < 0.001
21 - Injuries, Poison and Toxic Effect of Drugs 439 151 (34.4) 0.75 (0.62–0.98) 0.005
23 - Factors Influencing Health Status and Other Contacts Health Services 803 282 (35.1) 0.78 (0.67–0.90) 0.004
24 –Human Immunodeficiency Virus Infection 197 112 (56.9) 1.90 (1.43–2.52) < 0.001
25 - Multiple Significant Trauma 22 14 (63.6) 2.52 (1.06–6.00) 0.048

The diagnoses in each MDC correspond to a single organ system or cause, fundamentally based on the main diagnosis on admission. Therefore, there is only one MDC for each hospitalization episode.