Table 1. Comparison of existing aptamer predictive studies.

Algorithm	Aptamer Dataset	No-aptamer Dataset	Some Features	Classifier	MCC
This Study	DNA aptamers (n = 238)	Protein binding DNA (n = 4885)	6-mers for all sequences, Sequence features	Support Vector Machines	0.896
[35]	DNA/RNA aptamers (n = 159) Small Molecule Targets (n = 20)	Randomly paired aptamers to Small Molecule targets	1,2-mers for aptamers, Physical-chemical properties of targets	Nearest Neighbors	0.670
[57]	DNA/RNA aptamers (n = 725) Protein Targets (n = 164)	Randomly paired aptamers to protein targets	1,2-mers for aptamers, 1,2-mers for targets Physical-chemical properties of targets	Random Forest	0.461