Table 4. Top predictive features (6-mers), their reported structural function and contribution.

Predictive Sequence	Reported Structural Function	References
TGG TGG	A section of a G-quadruplex that interacts with Thrombin	[58]
TGG GGG	A section of a hairpin loop.	[10,59]
GGG GTG	A section of a hairpin loop that interacts with Thrombin and VEGF.	[60]
GGT TGG	Complimentary chain in the G-quadruplex the two thymine (T) residues interact with Thrombin.	[58,60,61]
GGG GGG	A small section of the hairpin loop that interacts with HIV-1 reverse transcriptase.	[62]