TABLE 1.
Baseline characteristics.
| Characteristics | Value N (%) or mean ± SD | |||
|---|---|---|---|---|
| Total (N = 5,104) | Low FT3 (N = 326) | Normal FT3(N = 4,778) | p Value | |
| Demographic data | ||||
| Age | 64.17 ± 10.61 | 69.79 ± 9.35 | 63.79 ± 10.57 | <0.0001 |
| Sex (male) | 3,886 (76.3%) | 224 (69.14%) | 3,632 (76.84%) | 0.0017 |
| BMI, kg/m2 | 24.68 ± 4.99 | 23.84 ± 4.59 | 24.73 ± 5.02 | 0.0005 |
| Smoke | 977 (21.72%) | 56 (22.13%) | 912 (21.69%) | 0.8695 |
| Comorbidities | ||||
| Arrhythmia | 481 (9.43%) | 42 (12.88%) | 435 (9.19%) | 0.0272 |
| Diabetes | 1,425 (27.92%) | 110 (33.74%) | 1,300 (27.46%) | 0.052 |
| Heart failure | 346 (6.78%) | 46 (14.11%) | 295 (6.23%) | <0.0001 |
| Hypertension | 3,053 (59.82%) | 213 (65.34%) | 2,811 (59.35%) | 0.0356 |
| Hyperlipidemia | 623 (12.21%) | 32 (9.82%) | 589 (12.44%) | 0.173 |
| Baseline biochemical measurements | ||||
| ALT, U/L | 31.31 ± 32.69 | 41.09 ± 66.79 | 30.67 ± 28.89 | 0.1013 |
| AST, U/L | 35.64 ± 55.71 | 59.37 ± 106.21 | 34.07 ± 50.29 | <0.0001 |
| CK, U/L | 173.38 ± 435.84 | 296.58 ± 620.98 | 165.63 ± 420.73 | 0.0497 |
| eGFR, ml/min/1.73 m2 | 100.37 ± 365.33 | 66.62 ± 29.07 | 102.94 ± 379.86 | <0.0001 |
| CKMB, U/L | 10.52 ± 18.4 | 13 ± 24.26 | 10.37 ± 18 | 0.5443 |
| CHOL, mmol/L | 4.48 ± 1.21 | 4.51 ± 1.51 | 4.48 ± 1.19 | 0.5021 |
| LDLC, mmol/L | 2.76 ± 0.97 | 2.73 ± 1.14 | 2.77 ± 0.96 | 0.0769 |
| HDLC, mmol/L | 0.98 ± 0.24 | 0.96 ± 0.27 | 0.99 ± 0.24 | 0.0566 |
| TRIG, mmol/L | 1.68 ± 1.31 | 1.61 ± 1.52 | 1.69 ± 1.29 | 0.0007 |
| GLUC, mmol/L | 6.79 ± 2.99 | 7.43 ± 3.22 | 6.74 ± 2.97 | <0.0001 |
| Lpa, mg/L | 290.4 ± 325.83 | 353.84 ± 377.45 | 286.53 ± 321.31 | 0.0004 |
| APOA, g/L | 1.09 ± 0.26 | 1 ± 0.26 | 1.09 ± 0.26 | <0.0001 |
| TSH,mu/L | 1.93 ± 3.47 | 3.72 ± 10.68 | 1.82 ± 2.22 | 0.5547 |
| FT4,pmol/L | 11.72 ± 2.86 | 11.85 ± 3.29 | 11.62 ± 2.22 | 0.0856 |
| Medication | ||||
| β-blockers | 3,746 (76.39%) | 258 (79.63%) | 3,457 (76.16%) | 0.155 |
| ACEIs | 2,612 (53.32%) | 195 (60.19%) | 2,394 (52.8%) | 0.0103 |
| CCBs | 1,458 (29.76%) | 111 (34.26%) | 1,334 (29.42%) | 0.0669 |
| PPIs | 2,356 (48.09%) | 206 (63.58%) | 2,136 (47.11%) | <0.0001 |
SD = standard deviation; BMI = body mass index; ALT = alanine aminotransferase; AST = aspartate aminotransferase; CK = creatine kinase; eGFR = estimated glomerular filtration rate; CKMB = creatine kinase MB; CHOL = cholesterol; LDLC = low-density lipoprotein cholesterol; HDLC = high-density lipoprotein cholesterol; TRIG = triglyceride; GLUC = glucose; Lpa = lipoprotein (a); APOA = apolipoprotein a; ACEIs = angiotensin converting enzyme inhibitors; CCBs = calcium channel blockers; PPIs = proton pump inhibitors.