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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: Nucl Med Biol. 2020 Sep 1;92:228–240. doi: 10.1016/j.nucmedbio.2020.08.004

Figure 5.

Figure 5.

225Ac-IA-TLs result in BBB opening in immunocompetent mice. A. BBB opening in immunocompetent mice infused with 225Ac-IA-TLs 2 days, 5 days and 10 days post injection compared to saline infused immunocompetent mice as demonstrated by intraveneously injected Evans Blue dye. Site of intracranial injection marked by yellow arrows. B and C: Area and intensity of Evans Blue dye was found to be greater in mice that were intracranially infused with 225Ac-IA-TLs when compared with the saline control up to 10 days postinfusion62.