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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: Cell Rep. 2021 Jul 27;36(4):109420. doi: 10.1016/j.celrep.2021.109420

Figure 1. Dysregulated Glycine and Oxalate Metabolism in Patients and Mice with Atherosclerosis.

Figure 1.

(A) Schematic representation of glycine metabolic pathways.

(B-E) Targeted metabolomics assessing the ratios of glycine to (B) serine, (C) threonine, (D) alanine and (E) oxalate in serum from age- and sex-matched patients with or without sCAD (n=24).

(F) En face analysis of atherosclerotic lesions in male Apoe−/− mice fed a standard diet (SD) or Western diet (WD) for 12 weeks (n=5).

(G-J) Targeted metabolomics assessing the ratios of glycine to (G) serine, (H) threonine, (I) alanine and (J) oxalate in plasma from male Apoe−/− mice fed a SD or WD for 12 weeks (n=5).

(K) Western blot analysis of AGXT protein abundance in livers from Apoe−/− mice fed a SD or WD for 12 weeks (n=5).

Mann-Whitney U test for B-E, G, H and K. Unpaired t test for F, I, J. Data are presented as mean ± SEM. All points and P values are shown.