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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: Cell Rep. 2021 Jul 27;36(4):109420. doi: 10.1016/j.celrep.2021.109420

Figure 6: AAV-mediated Overexpression of AGXT Reduces Oxidative Stress and Inflammation.

Figure 6:

AAV-AGXT or AAV-GFP were injected into male Apoe−/− mice and the mice were fed a WD for 12 weeks (n=8).

(A) Western blot analysis confirming the overexpression of AGXT in livers from mice treated with AAV-AGXT.

(B) Plasma glycine/oxalate ratio.

(C-D) qPCR analyses of genes regulating (C) redox homeostasis and (D) inflammatory responses. Gene expression levels were normalized to 18S.

(E-F) Plasma concentrations of (E) CCL2 and (F) CCL5.

(G) DHE fluorescence and Mac-2 immunofluorescence in the aortic sinuses (scale bar: 50 μm).

Data are presented as mean ± SEM. All points are shown. *P<0.05, **P<0.01, ***P<0.001 vs. AAV-GFP.