TABLE 2.
Characteristics of exclusion criteria observed during digital image analysis PQC (N = 123).
| One exclusion criterion | Extent | N (%) |
|---|---|---|
| No or fewer than 100 MCs | Entire sample | 42 (34.15) |
| Small biopsy size (< 1 mm2) | Entire sample | 16 (13.01) |
| Tissue availability after staining | Entire sample | 14 (11.38) |
| Fibrotic tissue without inflammatory cells | More than 80% | 12 (9.76) |
| Necrotic tissue | More than 80% | 11 (8.94) |
| Fragmented biopsy | Entire sample | 2 (1.63) |
| Staining artifact of oxidation/desiccation | Entire sample | 2 (1.63) |
| Crushed cells artifact | Entire sample | 2 (1.63) |
| Mostly hemorrhagic tissue | Entire sample | 1 (0.81) |
| Two exclusion criteria | ||
| No MCs or fewer than 100 MCs and fibrotic tissue without inflammatory cells | More than 80% | 7 (5.69) |
| Necrotic tissue and fibrotic tissue without inflammatory cells | Entire sample | 4 (3.25) |
| Fragmented biopsy and staining artifact of oxidation/desiccation | Entire sample | 3 (2.44) |
| Small biopsy size and necrotic tissue | More than 80% | 2 (1.63) |
| Necrotic tissue and crushed cells artifact | Entire sample | 2 (1.63) |
| Small biopsy size and fibrotic tissue without inflammatory cells | More than 80% | 1 (0.81) |
| No MCs or fewer than 100 MCs and necrotic tissue | More than 80% | 1 (0.81) |
| Staining artifact of oxidation/desiccation and crushed cells artifact | Entire tissue | 1 (0.81) |
| Total | 123 | 123 (100) |
PQC, pathology quality control; MC, malignant cell.