Table 3.
Comparison of Cohort 2 sign and symptom characteristics at time of illness presentation for children with GAS1 colonization with a new GAS emm-type and those with a previous GAS emm-type.
| Symptom Characteristics | New GAS emm-type Carrier2
N=113 |
Previous GAS emm-type Carrier N=103 |
OR4 (95% CI5) |
|---|---|---|---|
|
| |||
| Sore Throat6 Mild Moderate/Severe |
0 (0) 11 (100) |
5 (50) 5 (50) |
ref No estimate |
| Abnormal Pharyngeal Exam7 | 8 (73) | 8 (80) | 1.5 (0.2–11.5) |
| Fever6 | 2 (18) | 1 (10) | 0.5 (0.0–6.5) |
| Headache6 | 3 (27) | 0 (0) | No estimate |
| Abdominal Pain6 | 2 (18) | 1 (10) | 0.5 (0.0–6.5) |
| Vomiting6 | 2 (18) | 0 (0) | No estimate |
| Activity6 Normal Decreased |
7 (64) 4 (36) |
9 (90) 1 (10) |
ref 0.2 (0.0–2.2) |
| Cough6,8 | 3 (27) | 7 (78) | 9.3 (1.2–73.0) |
| Nasal Congestion6 | 4 (36) | 8 (80) | 7.0 (1.0–50.6) |
| One URI9 Symptom10 | 5 (45) | 9 (90) | 10.8 (1.0–117.0) |
| Two URI Symptoms10 | 2 (18) | 6 (67) | 9 (1.1–71.0) |
GAS: group A Streptococcus
Columns N (%) except where otherwise specified.
One child with new GAS emm-type carriage and two children with established GAS emm-type carriage had missing symptom data and were excluded from this comparison.
OR: odds ratio; estimated using Fisher’s exact test
CI: confidence interval
Patient/parent reported
Presence of erythema, enanthem, edema, petechiae or exudates present on the uvula, palate, tonsils or tongue as noted by trained research staff.
Missing cough data on one child
URI: upper respiratory infection
Symptoms include cough or nasal congestion