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. Author manuscript; available in PMC: 2021 Aug 13.
Published in final edited form as: Ageing Res Rev. 2020 May 4;61:101067. doi: 10.1016/j.arr.2020.101067

Figure 4. Tackling Network Alterations and Proteinopathy Overnight.

Figure 4.

tES can be optimized to tackle alterations of spatio-temporal functional networks as those recorded via resting-state fMRI, with particular emphasis on networks previously shown as altered in healthy and pathological aging, e.g. the default mode and ventral attention networks (panel A). Given the relevance of protein clearance processes overnight, and the recent discovery of dominant oscillatory activity (i.e. theta activity) accompanying CSF clearance dynamics during sleep, tES could also be tailored to target individual tau and amyloid accumulation overnight by maximizing stimulation over regions with higher tracer uptake at PET imaging (panel B).