Table 3.
Logistic regression analyses of the association between PAGln levels and overall WMH.
| P value | OR | 95% CI for OR | ||
|---|---|---|---|---|
| Lower | Upper | |||
| Unadjusted model | ||||
| PAGln levels | ||||
| First quartile | Reference | |||
| Second quartile | 0.001 | 2.212 | 1.390 | 3.522 |
| Third quartile | 0.061 | 1.559 | 0.980 | 2.479 |
| Fourth quartile | <0.001 | 4.296 | 2.639 | 6.994 |
| Adjusted model a | ||||
| PAGln levels | ||||
| First quartile | Reference | |||
| Second quartile | 0.020 | 1.818 | 1.098 | 3.010 |
| Third quartile | 0.755 | 0.921 | 0.549 | 1.544 |
| Fourth quartile | 0.009 | 2.053 | 1.195 | 3.528 |
| Age (years) | <0.001 | 1.080 | 1.059 | 1.100 |
| Sex (male) | 0.781 | 0.946 | 0.642 | 1.396 |
| Adjusted model b | ||||
| PAGln levels | ||||
| First quartile | Reference | |||
| Second quartile | 0.085 | 1.670 | 0.932 | 2.994 |
| Third quartile | 0.963 | 0.986 | 0.547 | 1.778 |
| Fourth quartile | 0.019 | 2.134 | 1.134 | 4.018 |
| Age (years) | <0.001 | 1.065 | 1.041 | 1.089 |
| Sex (male vs. female) | 0.324 | 0.776 | 0.469 | 1.285 |
| HBP | 0.399 | 1.235 | 0.757 | 2.015 |
| DM | 0.804 | 1.060 | 0.668 | 1.685 |
| CAD | 0.799 | 1.077 | 0.610 | 1.900 |
| Platelet >204 ×109 /L | 0.195 | 0.755 | 0.494 | 1.155 |
| eGFR ≤ 83.85 mL/min/1.73 m2 | 0.125 | 1.421 | 0.908 | 2.224 |
| TG >1.52 mmol/L | 0.262 | 0.785 | 0.514 | 1.198 |
| Homocysteine >13.28 μmol/L | 0.181 | 1.359 | 0.867 | 2.129 |
a
Adjusted modela: adjusted for age and sex.
b
Adjusted modelb: adjusted for age, sex, HBP, DM, CAD, platelet counts, eGFR, TG, and homocysteine levels.
WMH, white matter hyperintensity; OR, odds ratio; CI, confidence interval; PAGln, phenylacetylglutamine; HBP, hypertension; DM, diabetes mellitus; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; TG, triglycerides.